Speaker: Pedro J. Gutiérrez Diez – Department of Economic Theory / Mathematical Research Institute (IMUVa) – University of Valladolid
Title: Analysis of the epigenetic changes in the breast after pregnancy
Abstract: Full-term pregnancy at an early age (FFTP) confers long-term protection against breast cancer, being a guide for research on cancer prevention. The correct design of strategies based on this protective effect of pregnancy requires the characterization of its genomic consequences. In this respect, published literature suggests that pregnancy causes a specific transcriptomic profile controlling chromatin remodeling after pregnancy, therefore implying multiple and complex changes in gene expressions. In this research we analyze from several perspectives the modifications in the gene expression after FFTP, concluding that, independently of the changes in the gene expression at the individual level usually considered, there are significant changes in gene-gene interactions and gene cluster behaviors.